Molecule Found In Beef And Dairy Can Kill Cancer Cells, Study Suggests
According to a new study, a molecule found in beef and dairy improves the immune response to cancer.
“Scientists at UChicago discover that trans-vaccenic acid (TVA), a fatty acid found in beef, lamb, and dairy products, improves the ability of immune cells to fight tumors,” The University of Chicago Biological Sciences Division wrote Wednesday.
The researchers determined that “cancer patients with higher levels of the compound in their blood responded better to treatment, suggesting that it could have major benefits as a nutritional supplement,” Daily Mail reports.
WATCH:
“The research, published this week in Nature, also shows that patients with higher levels of TVA circulating in the blood responded better to immunotherapy, suggesting that it could have potential as a nutritional supplement to complement clinical treatments for cancer,” The University of Chicago Biological Sciences Division stated.
“There are many studies trying to decipher the link between diet and human health, and it’s very difficult to understand the underlying mechanisms because of the wide variety of foods people eat. But if we focus on just the nutrients and metabolites derived from food, we begin to see how they influence physiology and pathology,” said Jing Chen, PhD, the Janet Davison Rowley Distinguished Service Professor of Medicine at UChicago and one of the senior authors of the new study.
“By focusing on nutrients that can activate T cell responses, we found one that actually enhances anti-tumor immunity by activating an important immune pathway,” Chen added.
From The University of Chicago Biological Sciences Division:
Chen’s lab focuses on understanding how metabolites, nutrients and other molecules circulating in the blood influence the development of cancer and response to cancer treatments. For the new study, two postdoctoral fellows, Hao Fan, PhD and Siyuan Xia, PhD, both co-first authors, assembled a “blood nutrient” compound library consisting of 255 bioactive molecules derived from nutrients. They screened the compounds in this new library for their ability to influence anti-tumor immunity by activating CD8+ T cells, a group of immune cells critical for killing cancerous or virally infected cells.
After the scientists evaluated the top six candidates in both human and mouse cells, they saw that TVA performed the best. TVA is the most abundant trans fatty acid present in human milk, but the body cannot produce it on its own. Only about 20% of TVA is broken down into other byproducts, leaving 80% circulating in the blood. “That means there must be something else it does, so we started working on it more,” Chen said.
The researchers then conducted a series of experiments with cells and mouse models of diverse tumor types. Feeding mice a diet enriched with TVA significantly reduced the tumor growth potential of melanoma and colon cancer cells compared to mice fed a control diet. The TVA diet also enhanced the ability of CD8+ T cells to infiltrate tumors.
The team also performed a series of molecular and genetic analyses to understand how TVA was affecting the T cells. These included a new technique for monitoring transcription of single-stranded DNA called kethoxal-assisted single-stranded DNA sequencing, or KAS-seq, developed by Chuan He, PhD, the John T. Wilson Distinguished Service Professor of Chemistry at UChicago and another senior author of the study. These additional assays, done by both the Chen and He labs, showed that TVA inactivates a receptor on the cell surface called GPR43 which is usually activated by short-chain fatty acids often produced by gut microbiota. TVA overpowers these short-chain fatty acids and activates a cellular signaling process known as the CREB pathway, which is involved in a variety of functions including cellular growth, survival, and differentiation. The team also showed that mouse models where the GPR43 receptor was exclusively removed from CD8+ T cells also lacked their improved tumor fighting ability.
Daily Mail reports:
Fatty cuts of beef and lamb are more likely to have higher levels of TVA compared to lean cuts, as are whole milk and full-fat dairy products compared to low-fat and skim.
The anti-cancer power of the dairy-derived fatty acid comes from its ability to turbocharge certain immune cells known as T cells, which recognize foreign invaders and prompt the immune system to kill them.
Researchers said that eating foods rich in this compound or giving it to cancer patients as a supplement could have measurable benefits in decreasing the size of tumors.
Dr Jing Chen, senior author of the study, said: ‘By focusing on nutrients that can activate T cell responses, we found one that actually enhances anti-tumor immunity by activating an important immune pathway.’
Her team identified the nutrient after combing through a database of around 700 different metabolites – substances produced when the body breaks down food – all of which came from food.
Read the abstract for the study, titled “Trans-vaccenic acid reprograms CD8+ T cells and anti-tumour immunity,” at Nature:
Diet-derived nutrients are inextricably linked to human physiology by providing energy and biosynthetic building blocks and by functioning as regulatory molecules. However, the mechanisms by which circulating nutrients in the human body influence specific physiological processes remain largely unknown. Here we use a blood nutrient compound library-based screening approach to demonstrate that dietary trans-vaccenic acid (TVA) directly promotes effector CD8+ T cell function and anti-tumour immunity in vivo. TVA is the predominant form of trans-fatty acids enriched in human milk, but the human body cannot produce TVA endogenously1. Circulating TVA in humans is mainly from ruminant-derived foods including beef, lamb and dairy products such as milk and butter2,3, but only around 19% or 12% of dietary TVA is converted to rumenic acid by humans or mice, respectively4,5. Mechanistically, TVA inactivates the cell-surface receptor GPR43, an immunomodulatory G protein-coupled receptor activated by its short-chain fatty acid ligands6,7,8. TVA thus antagonizes the short-chain fatty acid agonists of GPR43, leading to activation of the cAMP–PKA–CREB axis for enhanced CD8+ T cell function. These findings reveal that diet-derived TVA represents a mechanism for host-extrinsic reprogramming of CD8+ T cells as opposed to the intrahost gut microbiota-derived short-chain fatty acids. TVA thus has translational potential for the treatment of tumours.
RELATED (now is it starting to make sense why they want to BAN red meat?):
Have You Heard Of “Ruminant Meats”?
Have you heard of “Ruminant Meats”?
I like to think I stay up on things, but that was a new term for me, which I just learned today.
And it actually blew my mind. 
Perhaps I can blow your mind too….
Listen to this INCREDIBLE video explaining all the benefits and then ask yourself: “Does it make sense now why they’re trying so hard to BAN red meat?”
Here’s more on their incredible health benefits:
Ruminant meats, derived from animals with a specialized stomach known as the rumen, include beef, lamb, goat, and venison. These meats are known for their distinctive flavor and nutritional content. Here’s an overview of their benefits:
- High-Quality Protein: Ruminant meats are excellent sources of high-quality protein, essential for muscle growth, repair, and overall health. The protein in these meats contains all the essential amino acids needed by the human body.
- Rich in Vitamins and Minerals: These meats are rich in essential nutrients, including B vitamins (particularly B12), zinc, and iron. Vitamin B12 is crucial for nerve function and blood cell formation, while zinc and iron are vital for immune health and oxygen transportation in the blood, respectively.
- Source of Healthy Fats: Ruminant meats contain various fats, including omega-3 fatty acids, particularly in grass-fed varieties. These healthy fats are important for brain health and reducing inflammation.
- Conjugated Linoleic Acid (CLA): Grass-fed ruminant meats are a good source of CLA, a type of fat that has been linked to reduced body fat and improved immune function.
- Creatine and Carnosine: These meats are natural sources of creatine and carnosine, compounds beneficial for muscle and brain health.
- Satiety and Weight Management: The high protein and fat content in ruminant meats can lead to greater feelings of fullness, which can help with weight management by reducing overall calorie intake.
- Sustainable Farming Practices: When ruminant animals are raised in sustainable, grass-fed systems, they can contribute to the health of the ecosystem through natural grazing and fertilization processes.
So…now does it make sense why they want to ban red meat so much?
Of of course the Elites will still eat it!
But they need you WEAK and STRUGGLING.
Not me.
I will eat red meat until the day I die…and I am going to enjoy every bite along the way!
That would be REAL RED MEAT as God made it, not Plant Based Meat.
Joe Rogan Calls It Out: “Plant Based Meat Is REALLY Bad For You!”
Why do people like Bill Gates and all others on the Far Left with “God Complexes”
feel the need to constantly reinvent meat?
They constantly want to play God, to create meat better than what God gave us.
Genesis makes very clear that God created plants and animals for our food, but that’s never good enough.
They always have to try and do their own version.
“Plant based meat”
“Lab grown beef”
“3D printed beef”
They’re throwing it all at us and I’m not touching ANY of it!
How about you?
Oh, not only that but they’ve killed so many cattle that we are at the LOWEST number of Beef Cattle on record since 1962!
Gee, you think that might have a big impact on prices?
Yup.
Now back to “Plant Based Meat”.
Think it’s good for you?
Think it’s healthy?
Think it’s good for the environment?
Wrong, Wrong and Wrong!
Watch this:
Now sometimes you just gotta laugh….
I love this reply:
The fact that “plant based meat” doesn’t exist anywhere in nature should tell you all you need to know:
But what do you do when red meat is disappearing from store shelves?
Being replaced with Lab Grown Meat?
Or Plant Based Meat?
Or mRNA injected Meat?
And even if you can find it, the prices are going through the roof! Just remember to buy local beef.
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